细胞株是连接生物药分子研发与工艺开发的关键纽带，一个稳定且高表达的细胞株无疑是开发出一套既可靠又经济的生产工艺的重要基础。在开发一个生物药时，开发者通常都希望以最快的速度获得这样一个质量优良的哺乳动物细胞株，同时又不失灵活性。苏州智享已经建立了一个成熟的细胞工程技术平台，开发过超过50个细胞株项目，几乎涵盖目前所有的治疗性蛋白种类。我们拥有多种CHO细胞株以及不同的表达系统，可以满足客户的不同需求，同时我们还具备cGMP细胞建库能力。我们会是您理想的选择。
Cell line is the vital link between lead molecule discovery and biologic process development. A stable, high-performing cell line can definitely provide a thorough grounding in developing robust, cost-effective manufacturing processes. Drug developers need rapid availability of mammalian cell lines in such quality grade, and flexibility. With a mature cell engineering technology platform and more than 50 programs experience, covering almost all types of therapeutic proteins as far, IntellectiveBio is the ideal partner for your mammalian cell culture projects. We have multiple CHO (Chinese Hamster Ovary) cell lines and various expression systems, which help meet clients’ different requirements, as well as cGMP cell banking capability.
快速、灵活且有质量保证的细胞株开发可以为后续工艺开发建立一个良好的开端。苏州智享专业提供全面的基因构建、质粒稳转、克隆筛选和评估等服务。
Establishing a sustainable process begins with cell line development that is built on speed, flexibility, and performance. Our expertise spans gene construction, stable transfection, clone screening and evaluation.
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只需简单的许可协议即可免费使用商业化细胞株，灵活使用，较少限制
Simple cell line commercial licensing agreements that avoid royalties, with use flexibility and limited restrictions
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多种宿主细胞选择，包括CHO-K1, CHO-S, CHO-DG44以及其他第三方开发的细胞株
A variety of host cell lines, including CHO-K1, CHO-S, CHO-DG44, and third-party-developed cell lines
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GS-, DHFR-, fut-等特殊表达系统，满足不同抗体或融合蛋白的功能需求
Special expression systems, including GS-, DHFR-, fut-, which are suitable for functional needs of different antibody or fusion protein
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全自动高通量铺板系统帮助高效进行细胞株构建和克隆筛选，使得从分子到确定最终克隆最快仅需11周
Automated high-throughput clone plating system that contributes to efficient cell line construction and selection of top clone, making the timeline from molecule to top clone within 11 weeks possible
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细胞拍照设备验证单克隆性，以支持IND申报
Cell imaging to verify monoclonicity and support IND filing
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与细胞株长期稳定性评价平台、细胞培养工艺开发平台紧密配合，确保细胞株具有更好的稳健性以及反应器流加培养可重复的表达量（2.5~6.0 g/L）
Seamless cooperation with cell line stability evaluation and cell culture process development guarantees a robust cell line and repeatable bioreactor fed-batch titer up to 2.5~6.0 g/L
